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Tuesday, April 21, 2020 | History

5 edition of Mechanisms of immunity to virus-induced tumors found in the catalog.

Mechanisms of immunity to virus-induced tumors

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  • 30 Currently reading

Published by M. Dekker in New York .
Written in English

    Subjects:
  • Tumors -- Immunological aspects.,
  • Oncogenic viruses.,
  • Tumor antigens.,
  • Immune response.,
  • Neoplasms -- Immunology.,
  • Oncogenic viruses.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by John W. Blasecki.
    SeriesImmunology series ;, v. 12
    ContributionsBlasecki, John W., 1943-
    Classifications
    LC ClassificationsQR188.6 .M4
    The Physical Object
    Paginationix, 356 p. ;
    Number of Pages356
    ID Numbers
    Open LibraryOL4254846M
    ISBN 100824711629
    LC Control Number81000163
    OCLC/WorldCa7248511

    There is increasing evidence of a pivotal regulatory role of innate immune mechanisms in tumor-immune interplay. Among these diverse mechanisms, tumor-derived nucleic acids’ sensing has recently emerged as one of the fundamental pathways linking innate and adaptive immunity, with DNA-sensor STING being the crucial member of this pathway. Another clear trend is understanding the Author: Olga Kurmyshkina, Pavel Kovchur, Ludmila Schegoleva, TatyanaVolkova. Hence, the increased risk of immune-compromised individuals to develop EBV-associated tumors indicates loss of EBV-specific immune control that normally prevents viral tumorigenesis. T cells constitute the decisive component of EBV-specific immune control against virus-associated malignancies because adoptive transfer of EBV-specific T cell Cited by:


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Mechanisms of immunity to virus-induced tumors Download PDF EPUB FB2

Additional Physical Format: Online version: Mechanisms of immunity to virus-induced tumors. New York: M. Dekker, © (OCoLC) Document Type. It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance, but also limits the Mechanisms of immunity to virus-induced tumors book of cancer immunotherapy.

Therefore, it is critically important to understand the mechanisms of tumor-induced immune suppression to make Mechanisms of immunity to virus-induced tumors book progress in the field and this monograph provides these important : Paperback. Induction of innate and adaptive immune responses. The initiation of the immune response to an invading microorganism like a virus requires that the host sense the organism and its constituents [e.g.

uncapped viral RNA ()] and/or cellular stress and consequent metabolic changes and cellular damage resulting from initial response to infection is carried out primarily by germline Cited by: Leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible clinical strategies to prevent or reverse tumor-induced immune dysfunction.

The authors review the mechanisms of immune dysfunction and evasion. Natural Cell-Mediated Immunity Against Tumors aims to be the first book to provide a comprehensive discussion on natural cell-mediated immunity against tumors.

This book is mostly a collection of different research contributed by leading laboratories. It also presents a better perspective of how natural mechanisms fit in with and relate to the. This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic.

The past decade has seen major advances in cancer immune checkpoint therapy. The first mechanism of tumor immune evasion to be recognized and studied involved the inhibition of tumor antigen presentation.

Downregulation of the antigen processing machinery—particularly the MHC class I pathway—has been documented extensively in a large variety of by: Tumor variants with reduced sensitivity to immune effectors.

3) Alteration of effector cell trafficking. B) Tumor variants that suppress the antitumor immune response. 3) Infiltration of suppressor myeloid cells.

4) Infiltration of T regulatory cells. 5) Production of immunosuppressive factorsFile Size: 7MB. The multiplicity of possible immune system-neoplastic cell interaction is unfortunately balanced by the multiplicity of mechanisms that serve to interfere with an effective immune response to tumors.

These mechanisms may reflect pathologic derangements of normal immunoregulatory processes or may involve the production of suppressive substances by the tumors by: 9. on viral tumors • Virus-induced tumors express cell surface antigens (distinct from antigens of the virion itself) which are shared by all tumors induced by the same virus.

These antigens are characteristic of the tumor-inducing virus, regardless of tissue origin of the tumor or animal species in which the tumor exists (Figure 1).File Size: 1MB. In recent years, this has caused researchers to look for a change in the status quo, and, the awareness of the human immune system, which has an intrinsic mechanism to control microbial pathogens and dysfunctional self-tissues, has triggered scientists to look for new modes of cancer : Jianxun Song, Adam W.

Mailloux, Anatoliy Markiv, Carol A. Kruse, Colin C. Malone, Elena I. Fomchenko. The progressive growth of a malignant tumor is accompanied by a decline in the immune response, through mechanisms that have, until recently, been poorly understood. The new era of biological therapies, including cytokines, adoptive transfer of TIL cells, gene therapy and others, brought forth the need to understand the impact of the tumor on the immune system.

The emergence of immune checkpoint blockade therapies over the last decade has transformed cancer treatment in a wide range of tumor types. Unprecedented and durable clinical responses in difficult-to-treat cancer histologies have been observed.

However, despite these promising long-term responses, the majority of patients fail to respond to immune checkpoint blockade, Cited by: Mechanisms of Immune Evasion by Tumors Article Literature Review in Advances in Immunology February with Reads How we measure 'reads'. Abstract.

Virally induced tumors provide the strongest case of host surveillance against neoplastic cells and their precursors. There is now substantial evidence that Epstein-Barr virus (EBV), hepatitis-B and C viruses (HBV and HCV), several types of papilloma viruses (HPV), Human Herpesvirus type 8 (HHV8) and human T-cell leukemia-lymphoma virus type I (HTLV I) and type II are responsible for Author: Maria G.

Masucci, Victor Levitsky, Teresa Frisan, Jelena Levistkaya, Pedro O. De Campos-Lima. The mechanisms by which oncogenes and TSGs orchestrate the inflammatory tumor microenvironment are now being uncovered. Specific cancer-associated genes, besides driving cancer cell-intrinsic programs, also change the secretome of cancer cells and thereby change the immune microenvironment (Figure 1, Table 2).Cited by: A brief review of tumor immunity, including the difinition, the tumor antigen, the mechanism of immune response to tumors and immune evasion mechanism by tumors, and immunotherapy for tumors.

of which can even attack their hosts) and why the immune system fails to reject malignant tumours (cancer). Finally, we turn from problems to solutions and introduce two areas in which either the intact immune system and components of immunity can be harnessed for our own benefit and from which tools can be derived to treat disease.

However, understanding the mechanisms used by tumor cells to evade the immune system could result in new therapeutic approaches for preventing and/or reversing these immune alterations and have the potential of improving the current results of immunotherapy by: Immune System and Immunology (PDF 63P) This note covers the following topics: Adaptve Defense Mechanisms, The Adaptive Immune Response, Vaccination, Immunoglobulin Classes, Immunoglobulin Diagnostics, Lymphatic System, T Cells And T Cell Receptor, Inadequate Defense, Disease Caused By Immune Reactions, Immune Complex Diseases, Damage By Cellular Immune Responses.

The immune response to cancer, on the other hand, has been more difficult to understand and control. Although it is clear that the immune system can recognize some cancers and control them, others seem to be resistant to immune mechanisms. The Rh Factor. Red blood cells can be typed based on their surface antigens.

Purchase Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - 1st Edition. Print Book & E-Book.

ISBNElucidates autophagy’s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases/5(2).

Tumor immunology is the study ofTumor immunology is the study of: immunity • Mechanisms of tumor evasion of theMechanisms of tumor evasion of the Chemical UV d i i i carcinogens UV and ionizing radiation Tumour induction Virus-induced (HepC, EBV, HPV) Genetic abnormalities (XP) Immunosuppression.

Tumors sometime express mutant File Size: 1MB. Principles o Vaccination. Passive Immunity. Passive immunity is the transfer of antibody produced by one human or other animal to another.

Passive immunity provides protection against some infections, but this protection is temporary. The antibodies will degrade during a period of weeks to months, and the recipient will no longer be Size: 97KB. The progressive growth of a malignant tumor is accompanied by a decline in the immune response, through mechanisms that have, until recently, been poorly understood.

The new era of biological therapies, including cytokines, adoptive transfer of TIL cells, gene therapy and others, brought forth the need to understand the impact of the tumor on.

To understand the genetic drivers of immune recognition and evasion in colorectal cancer (CRC), we analyzed 1, CRC primary tumor samples, including classified as microsatellite instability. MECHANISM OF TUMOR IMMUNITY The immune response that attacks nonself tumor cells is directed by T cells.

Such immune responses probably act as a surveillance system to detect and eliminate newly arising clones of neoplastic cells. Cancer immunology is an interdisciplinary branch of biology that is concerned with understanding the role of the immune system in the progression and development of cancer; the most well known application is cancer immunotherapy, which utilises the immune system as a treatment for immunosurveillance and immunoediting are based on protection against development of tumors in.

Tumors can evade immune system–mediated destruction despite expressing antigenic neoepitopes. Gajewski, Schreiber and Fu discuss how the tumor Cited by: Cancer is a leading cause of human deaths worldwide.

Besides inherited genetic disorders, a diverse range of physical, chemical and biological agents may induce cancer. About % of cancers are known to be originated due to pathogens. Viruses are considered to be the second (after smoking) most important risk factor in inducing human : Ram Kumar, Riyesh Thachamvally, Sunil Maherchandani, Bhupendra Nath Tripathi, Sanjay Barua, Naveen K.

T1 - Mechanisms of Immune Evasion by Tumors. AU - Drake, Charles G. AU - Jaffee, Elizabeth. AU - Pardoll, Drew M. PY - /5/ Y1 - /5/ N2 - In the past decade, basic studies in animal models have begun to elucidate the physiological barriers which impede a successful antitumor immune Cited by:   This lecture discusses immune surveillance, cancer cell management, escape mechanism and immunotherapy.

Category Mechanism of Cancer (tumor suppressor genes and oncogenes) - Duration: Immunity to Cancer documents the proceedings of a conference on ""Immunity to Cancer"" held at Williamsburg, Virginia, SeptemberThis was the first open conference since the New York Academy of Sciences meeting in that attempted to address the entire range of topics encompassed by tumor immunology and immunotherapy.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Vol. 1: Molecular Mechanisms M. Hayat (Eds.). Thorsson et al. present immunogenomics analyses of more t tumors, identifying six immune subtypes that encompass multiple cancer types and are hypothesized to define immune response patterns impacting prognosis.

This work provides a resource for understanding tumor-immune interactions, with implications for identifying ways to advance research on by: An overview of mechanisms responsible for tumor dormancy / E. Frederick Wheelock --A pathologist's view of tumor dormancy / Raymond Yesner --Dormancy in experimental solid tumor systems / Duzanne A.

Eccles --Immune regulation of a murine T-cell lymphoma dormant state / E. Frederick Wheelock, Guchen Yang and Lieping Chen --Idiotypic vaccination. The immune system is a host defense system comprising many biological structures and processes within an organism that protects against function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy many species, there are two major subsystems of the immune.

Controversial role in antitumor immunity. The role of CD4 + T cells in antitumor immunity is controversial. It was suggested that CD4 + T cells can have a direct role in antitumor immunity through direct recognition of tumor antigens presented on the surface of tumor cells in association with MHC class II molecules.

Of note, results from recent reports suggest that direct recognition of tumors. Recent success of immunotherapy strategies such as immune checkpoint blockade in several malignancies has established the role of immunotherapy in the treatment of cancer.

Cancers use multiple mechanisms to co-opt the host-tumor immune interactions, leading to immune evasion. Our understanding of the host-tumor interactions has evolved over the past few years and led to various Cited by:. Describe mechanical, chemical, and microbiological mechanisms that act as a first line of defense for the immune system Describe the process of extravasation in general Cells roll along the endothelium by loosely attaching to selectin molecules.

However, there are some examples in which a given oncogene is frequently altered [e.g., c-myc in avian leukosis virus-induced bursal lymphomas; N-myc in woodchuck hepatitis virus-induced liver tumors ].

MMTV is a retrovirus that induces solid tumors (carcinomas) and is the cause of breast cancer Cited by: With an approach that covers the range from basic research to clinical applications, The Immune Response to Infection examines the mechanisms of both the innate and adaptive immune systems as they relate to infection and disease.

The book not only explores the underlying mechanisms of immunity, but also the many sequelae of host-pathogen interactions, ranging from the sterile .